Tag: biology

Growth Factor I, insulin sensitivity, life extension

Andrzej Bartke, a researcher in geriatrics, and his colleagues at Southern Illinois University in Springfield, are closing in on the genetic basis for and biochemical/endocrine prevention of aging in mammals .

For years it has been observed that calorie restriction could enhance longevity in rats and other animals (research history) but the mechanisms behind this effect were unknown.

In a 2006 article in the Proceedings of the National Acadamy of Sciences , they write

“there is considerable evidence that reduced secretion of insulin-like growth factor I and insulin are among the mechanisms that mediate the effects of Calorie Restriction (CR) on aging and longevity in mammals.”

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