Folic acid supplements in late pregnancy increase risk of asthma
According to CDC statistics, U.S. childhood asthma prevalence more than doubled between 1980 to the mid-1990s and has since plateaued at those historically high levels. Although many triggers and risk factors for asthma have been identified, the reasons behind this increase are not yet understood.
A recent study by University of Adelaide researchers Whitrow, Moore, Rumbold, and Davies may shed some light on the rise in asthma in young children. The study appears to show that the use of folic acid supplements in late pregnancy can lead to increased allergic asthma in children of 3.5 years of age. This human study corroborates earlier studies in mice which indicated that supplementation with folate in pregnancy leads to an allergic asthma phenotype in mice via epigenetic mechanisms (changes in gene expression).
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