Recent research on Alzheimers: Blocking an immune signaling chemical allows macrophages to clear plaques in mice
Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.
A new possible treatment target has been demonstrated by a group of researchers working with transgenic mice that are used to model Alzheimer’s in humans. According to New Scientist:
“Richard Flavell at Yale University and colleagues created transgenic mice predisposed to develop brain plaques, and doubly transgenic mice that also had a gene that blocks TGF-beta, a chemical used by the immune system.”
“The researchers expected the second set to fare worse than the first. But to their surprise, the doubly transgenic mice performed better on various mazes”…
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