Category: Misc.

Autism – anecdotal evidence and possible link to gastrointestinal infection

Research on the causes of autism is still at the stage where many etiologies seem possible. Althought a genetic link is likely, it may play a role of predisposition to another factor rather than being the only necessary and sufficient cause of autism.

One such connection being explored is the role of gastrointestinal infections in promoting autistic type behaviors.

This blog entry written by an occupational therapist refers to improvement in a young patient’s autistic type behaviors after she was treated for a Clostridium Bacteria infection.

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Recent research on Alzheimers: Blocking an immune signaling chemical allows macrophages to clear plaques in mice

Blocking TGF-β-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology.

A new possible treatment target has been demonstrated by a group of researchers working with transgenic mice that are used to model Alzheimer’s in humans. According to New Scientist:
“Richard Flavell at Yale University and colleagues created transgenic mice predisposed to develop brain plaques, and doubly transgenic mice that also had a gene that blocks TGF-beta, a chemical used by the immune system.”

“The researchers expected the second set to fare worse than the first. But to their surprise, the doubly transgenic mice performed better on various mazes”…

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Recent research on Alzheimer’s Disease: Inflammation, and the role of viral and bacterial infection

The last year saw some very exciting developments in Alzheimer’s research. Among them, the relationship of inflamation processes to cognitive decline and a possible relationship of the herpes simplex virus in the presence of a certain genotype to the development of Alzheimers.

Simon Cooke, who writes a blog called the "Accidental Scientist," has posted a very readable and informative summary of some of the most interesting highlights of the latest research. He does a great job of explaining the new discoveries, and speculates about links between infectious diseases and chronic diseases yet to be confirmed. In particular his post on the use of an anti-inflammatory drug to treat Alzheimers – in minutes!, and his post on the possible role of Herpes in many chronic diseases are particularly worth reading.

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